3-Amino-4-pyrazole carbosamide hemisulfate

Te takawaenga mo te whakahiato o te allopurinol.

Koia tetahi o nga raupapa pyrazole 3-amino-4-substituted.Ka taea te whakamahi hei takawaenga ki te whakahiato i te maha o nga puhui pararopi whai hua mo te rongoa, penei i te allopurinol, tetahi o nga raupapa pärönaki pyrazolopyrimidine, ko te whakamutunga mai i te tau 1963 Mai i tana whakamahinga haumanu, ko ia te rongoa matua mo te maimoatanga o te kauti.I tenei wa, he iti noa nga tikanga mo te whakahiato

Ko te 3-aminopyrazole-4-carboxamide hemisulfate i Haina, ko te nuinga ma te whakahoki i te malononitrile me te triethyl orthoformate ki te whakarite i te ethoxymethylene malononitrile, katahi me te Ko te tauhohenga o te hydrazine hydrate ka puta te 3-amino-4-cyanopyrazole, ka mutu te tauhohenga ki te waikawa waikawa konutai.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), te katoa o nga hua o te Ko te whakahiatotanga ma tenei tikanga e tata ana ki te 60% (kua tatauhia hei malononitrile), ko tenei tikanga Ka uru ki te tauhohenga e toru-taahiraa, he roa ake nga hikoi, me nga reagents e whakamahia ana, penei i te malononitrile me te ethoxymethylene malononitrile, he paitini me te utu nui.I tua atu, ko te 3-aminopyrazole-4 kua whakaritea e tenei tikanga -Formamide hemisulfate he tae he uaua ki te tango me te hiahia ki te tukatuka atu, he mea uaua ake.

He purongo kei roto i nga tuhinga o tawahi e whakamahi ana i te pyridylamide hydrazone me te ethoxymethylene malononitrile hei rauemi mata hei whiwhi 3-amino-4-cyanopyrazole ma te taapiri me te cyclization, katahi ka tauhohe ki te waikawa sulfuric concentrated ki te whiwhi i te pūhui ūnga (Reuken G Jones. Reactions of orthoesters with pūhui activemethylene [J] J Am Chem Soc. 1952,74(5) :4889 4891).Ko nga rauemi matua e whakamahia ana i roto i tenei tikanga he utu nui, kaore i te nui te hua o te tauhohenga, me te iti o te hua o te mahi ahumahi.Me uaua.