(R)-8-(3-Amino-piperidin-1-yl)-7-engari-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3
(R)-8-(3-Amino-piperidin-1-yl)-7-engari-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3
Linagliptin Ko Linagliptin, i hangaia e Boehringer Ingelheim, i whakamanahia e te FDA i te 2 o Mei, 2011. Ka whakamahia hei whakakotahi i te kai me te korikori tinana hei whakapai ake i te whakahaerenga o nga taumata huka toto i roto i nga tangata whai mate huka momo 2.Ko te Linagliptin te whakapai ake i te whakahaere o te huka toto i roto i nga turoro ma te aukati i te dipeptidyl peptidase-4 (DPP-4).
Ko te Incretin (Incretin) te whai hua ki te whakatairanga i te hunanga o te insulin e te pancreatic islet B cell, te nuinga tae atu ki te glucose-dependent insulinotropic polypeptide (GIP) me te glucagon-like polypeptide-1 (GLP-1).Ko te DDP-4 he protease serine kei te mata o nga pūtau.Ka herea ki nga pūmua, ka noho whanui i roto i te plasma me nga momo kopa o te tinana (pēnei i te whatukuhu, te ate, nga whekau iti, nga pūtau endothelial, me etahi atu).Ko te Linagliptin he aukati DPP-4 maataki e aukati ana i te mahi o te enzyme na roto i te hono whakamuri ki te DPP-4, ka whakaroa i te paheketanga o te GLP-1, ka whakarei ake i te mahi o te GLP-1, me te whakaihiihi i runga i te ahua o te hukahuka ka hunahia e te insulin. ka whakaheke i te taumata o te glucagon i roto i te tohanga, na reira ka whakatau i te taumata huka toto o nga turoro me te mate huka momo 2.
Ka whakatauritea ki etahi atu aukati DPP-4, ko nga painga nui o te Linagliptin ko: he pai te haumaru o nga whatukuhu ka taea te whakaiti i te hemoglobin glycosylated.Ko te Linagliptin te nuinga ka peehia i roto i nga feces i roto i te ahua prototype.I muri i te whakahaere a-waha, ko te 5% noa o te tangohanga o nga whatukuhu i tukuna.Ahakoa ka tukuna ki roto i te toto, ko te 30.8% anake ka tukuna ma nga whatukuhu.Na reira, kaore he hiahia mo nga turoro e whai maimoatanga ana.Tirohia te mahi ate me te whatukuhu me te whakarereketanga o te horopeta.Ka taea e nga turoro katoa te whakatika i te horopeta mo te ngawari o te whakahaunga.
Ko nga tauhohenga kino noa o te Linagliptin ko te mate manawa, te ihu, te mamae uaua, te mahunga me te korokoro.
Paerewa Kaiwhakahaere:paerewa hinonga
Whakatau:98-102%
Waho:Ma ki te kowhai te paura tioata
Mōkī:25kg/pahū
JIN DUN Medical kuaKo te tohu ISO me te whakatutuki i nga paerewa whakaputa GMP, e mahi ana i nga tohunga whakahiato raau taero o roto me tawahi me te whai wheako nui hei arahi i te R&D a te kamupene.
TE WHAKAMAHI OGY
●High Pressure Catalytic Hydrogenation .Tauhohenga Hydrogenolysis High Pressure.Tauhohenga Cryogenic (<-78%C)
●Hangai Heterocyclic Aromatic
●Rearrangement Reaction
●Tauira Hira
●Heck, Suzuki,Negishi,Sonogashira .Tauhohenga Gignard
Nga taputapu
He maha nga taputapu whakamatautau me te whakamatautau, penei i te: NMR (Bruker 400M) 、HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Te Ngaruiti Ngaruiti, Te Whakarara Whakarara, Te Waahanga Matawai Rereke (DSC), Te Kaitiaki Irahiko...
R&D Team
Kei a Jindun Medical he roopu o nga kaimahi R&D ngaio, a he maha nga tohunga whakahiato tarukino o roto me nga iwi ke ki te arahi i te R&D, kia tika ake ai, kia pai ake ai to taatau whakahiato.
Kua awhinahia e matou etahi kamupene rongoa o roto, penei iHansoh, Hengrui me HEC Pharm.I konei ka whakaatuhia e matou tetahi waahanga o ratou.
Whakaritenga Take Tuatahi:
Nama nama: 110351-94-5
Take Whakaritea Tuarua:
Nama nama: 144848-24-8
Ritenga Take Tuatoru:
Nama cas: 200636-54-0
1.Whakaritea nga Takawaenga Hou, API ranei.He rite ano ki te tiritiri keehi i runga ake nei, kei nga kaihoko nga tono mo nga Kaiwawao motuhake, API ranei, a kaore e kitea nga hua e hiahiatia ana i te maakete, katahi ka awhina taatau ki te Whakaritea.
2.Tukatuka Arotautanga mo nga Hua Tawhito.Ka awhina to taatau roopu ki te Whakapaipai me te whakapai ake i nga mahi penei kua tawhito te huarahi tauhohenga, he nui te utu whakaputa, he iti te mahi.Ka taea e matou te whakarato i nga tuhinga katoa mo te whakawhiti hangarau me te whakapai ake i te tukanga, awhina i te kaihoko mo te mahi pai ake.
Mai i nga whaainga tarukino ki nga IND, ka tukuna e JIN DUN Medical ki a koenga otinga R&D motuhake kotahi-mutu.
Kei te tohe a JIN DUN Medical ki te hanga i tetahi roopu me nga moemoea, ki te hanga i nga hua rangatira, ki te tino mohio, ki te kaha, me te mahi katoa hei hoa pono me te hoa o nga kaihoko!
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