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3-Amino-4-pyrazole carbosamide hemisulfate

3-Amino-4-pyrazole carbosamide hemisulfate

Whakaahuatanga Poto:

tātai rāpoi: C4H6N4O · ½H2SO4

Taumaha rāpoi:175.15

CAS KO:27511-79-1


Taipitopito Hua

Tohu Hua

Taupānga

Te takawaenga mo te whakahiato o te allopurinol.

Koia tetahi o nga raupapa pyrazole 3-amino-4-substituted.Ka taea te whakamahi hei takawaenga ki te whakahiato i te maha o nga puhui pararopi whai hua mo te rongoa, penei i te allopurinol, tetahi o nga raupapa pärönaki pyrazolopyrimidine, ko te whakamutunga mai i te tau 1963 Mai i tana whakamahinga haumanu, ko ia te rongoa matua mo te maimoatanga o te kauti.I tenei wa, he iti noa nga tikanga mo te whakahiato

Ko te 3-aminopyrazole-4-carboxamide hemisulfate i Haina, ko te nuinga ma te whakahoki i te malononitrile me te triethyl orthoformate ki te whakarite i te ethoxymethylene malononitrile, katahi me te Ko te tauhohenga o te hydrazine hydrate ka puta te 3-amino-4-cyanopyrazole, ka mutu te tauhohenga ki te waikawa waikawa konutai.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), te katoa o nga hua o te Ko te whakahiatotanga ma tenei tikanga e tata ana ki te 60% (kua tatauhia hei malononitrile), ko tenei tikanga Ka uru ki te tauhohenga e toru-taahiraa, he roa ake nga hikoi, me nga reagents e whakamahia ana, penei i te malononitrile me te ethoxymethylene malononitrile, he paitini me te utu nui.I tua atu, ko te 3-aminopyrazole-4 kua whakaritea e tenei tikanga -Formamide hemisulfate he tae he uaua ki te tango me te hiahia ki te tukatuka atu, he mea uaua ake.

He purongo kei roto i nga tuhinga o tawahi e whakamahi ana i te pyridylamide hydrazone me te ethoxymethylene malononitrile hei rauemi mata hei whiwhi 3-amino-4-cyanopyrazole ma te taapiri me te cyclization, katahi ka tauhohe ki te waikawa sulfuric concentrated ki te whiwhi i te pūhui ūnga (Reuken G Jones. Reactions of orthoesters with pūhui activemethylene [J] J Am Chem Soc. 1952,74(5) :4889 4891).Ko nga rauemi matua e whakamahia ana i roto i tenei tikanga he utu nui, kaore i te nui te hua o te tauhohenga, me te iti o te hua o te mahi ahumahi.Me uaua.

Paerewa Kaiwhakahaere:Paerewa hinonga
Waho:Te paura ma, kowhai ranei

Mōkī:25kg/pahū
whakamātautau (HPLC) ihirangi He nui ake i te rite ranei ki te 98.0%
parakore (HPLC) ihirangi Nui ake i te rite ranei ki te 99.5%

Raina Hua kua whakauruhia e te Rauemi

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Tiwhikete

JIN DUN Medical kuaKo te tohu ISO me te whakatutuki i nga paerewa whakaputa GMP, e mahi ana i nga tohunga whakahiato raau taero o roto me tawahi me te whai wheako nui hei arahi i te R&D a te kamupene.

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Painga mo te Whakaritenga Hauora

TE WHAKAMAHI OGY
●High Pressure Catalytic Hydrogenation .Tauhohenga Hydrogenolysis High Pressure.Tauhohenga Cryogenic (<-78%C)
●Hangai Heterocyclic Aromatic
●Rearrangement Reaction
●Tauira Hira
●Heck, Suzuki,Negishi,Sonogashira .Tauhohenga Gignard

JIN DUN R&D

Nga taputapu

He maha nga taputapu whakamatautau me te whakamatautau, penei i te: NMR (Bruker 400M) 、HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Te Ngaruiti Ngaruiti, Te Whakarara Whakarara, Te Waahanga Matawai Rereke (DSC), Te Kaitiaki Irahiko...

R&D Team

Kei a Jindun Medical he roopu o nga kaimahi R&D ngaio, a he maha nga tohunga whakahiato tarukino o roto me nga iwi ke ki te arahi i te R&D, kia tika ake ai, kia pai ake ai to taatau whakahiato.

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Tiri-take

Kua awhinahia e matou etahi kamupene rongoa o roto, penei iHansoh, Hengrui me HEC Pharm.I konei ka whakaatuhia e matou tetahi waahanga o ratou.

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Whakaritenga Take Tuatahi:

Nama nama: 110351-94-5

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Take Whakaritea Tuarua:

Nama nama: 144848-24-8

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Ritenga Take Tuatoru:

Nama cas: 200636-54-0

Aratau Mahi tahi

1.Whakaritea nga Takawaenga Hou, API ranei.He rite ano ki te tiritiri keehi i runga ake nei, kei nga kaihoko nga tono mo nga Kaiwawao motuhake, API ranei, a kaore e kitea nga hua e hiahiatia ana i te maakete, katahi ka awhina taatau ki te Whakaritea.

2.Tukatuka Arotautanga mo nga Hua Tawhito.Ka awhina to taatau roopu ki te Whakapaipai me te whakapai ake i nga mahi penei kua tawhito te huarahi tauhohenga, he nui te utu whakaputa, he iti te mahi.Ka taea e matou te whakarato i nga tuhinga katoa mo te whakawhiti hangarau me te whakapai ake i te tukanga, awhina i te kaihoko mo te mahi pai ake.

Mai i nga whaainga tarukino ki nga IND, ka tukuna e JIN DUN Medical ki a koenga otinga R&D motuhake kotahi-mutu.

Kei te tohe a JIN DUN Medical ki te hanga i tetahi roopu me nga moemoea, ki te hanga i nga hua rangatira, ki te tino mohio, ki te kaha, me te mahi katoa hei hoa pono me te hoa o nga kaihoko!


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