5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]- 5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2 (4h)-kotahi

5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]- 5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2 (4h)-kotahi ka whakamahia hei takawaenga o Prasugrel .
Ko te Prasugrel he antiplatelet thiophenopyridine i whakawhanakehia e Eli Lilly me daiichisankyo, he kaihanga rongoa Hapanihi.He rongoa kaamua.Ka hangaia he ngota ngota kaha i muri i te paopaotanga na roto i te cytochrome P450 i roto i te ate, ka hono atu ki te kaiawhina pereti P2Y12 kia kaha ai ki te whakahiato pereti.Kua whakaatuhia e nga rangahau haumanu he pai ake te paanga anticoagulant o te horopeta 60 mg i te 300 mg te horopeta paerewa me te 600 mg te nui ake o te horopeta o te clopidogrel, ka taea te whakaiti i te mate o te mate o te ngakau, te whiu me te mate na te mate o te ngakau ma te 20%, me te whai hua tere. , he pai te painga whakaora, he pai te aukati tarukino me te koiora, me te paitini iti.