I tenei wiki, i whakaputaina e te hautaka maatauranga matua Nature he pepa rangahau a-ipurangi na te roopu a Ahorangi Feng Liang i te Whare Wananga o Stanford, e whakaatu ana i te hanganga me te tikanga mahi o te pūmua kawe lipid arai toto-roro MFSD2A.Ka awhina tenei kitenga ki te hoahoa raau taero hei whakahaere i te uruhanga o te arai toto-roro.
Ko te MFSD2A he kaikawe phospholipid te kawenga mo te tango i te waikawa docosahexaenoic ki roto i te roro i roto i nga pūtau endothelial e hanga ana i te arai toto-roro.Ko te waikawa Docosahexaenoic e mohiotia ana ko DHA, he mea nui mo te whanaketanga me te mahi o te roro.Ko nga huringa ka pa ki te mahi a te MFSD2A ka puta he raruraru whanaketanga e kiia nei ko te microcephaly syndrome.
Ko te kaha o te kawe lipid o te MFSD2A ko te tikanga he hononga tata tenei pūmua ki te tika o te arai toto-roro.Kua kitea e nga rangahau o mua ka whakahekehia ana mahi, ka pakaru te arai toto-roro.No reira, ko te MFSD2A ka kiia he huringa mana whakahaere ina tika ana ki te whakawhiti i te arai toto-roro ki te tuku rongoa rongoa ki roto i te roro.
I roto i tenei rangahau, i whakamahia e te roopu a Ahorangi Feng Liang te hangarau moroiti cryo-electron ki te whiwhi i te hanganga taumira teitei o te kiore MFSD2A, e whakaatu ana i tana rohe extracellular ahurei me te kohao herea tïpako.
Ma te whakakotahi i te tātaritanga mahi me te whakahiatotanga o te whakahiato irapoi, i kitea ano e nga kairangahau nga waahi herea konutai i roto i te hanganga o te MFSD2A, e whakaatu ana i nga huarahi urunga lipid pea, me te awhina ki te mohio he aha te take i puta ai nga irakētanga MFSD2A motuhake i te mate microcephaly.
Wā tuku: Sep-01-2021