Guanosine

Ka whakamahia te Guanosine hei takawaenga o Valaciclovir.
Ko Valacyclovir he guanine analogue antiviral tarukino.Kei te whakamahia i roto i te maimoatanga haumanu o te herpes simplex me te mate herpes zoster i roto i nga mate o te taatai.Ko tenei hua te tohu o te acyclovir.Ka tere te ngongo i muri i te whakahaere a-waha, ka tere te huri hei acyclovir i roto i te tinana.Ko tana painga antiviral e takarohia ana e te acyclovir.Whai muri i te urunga o te acyclovir ki nga pūtau kua pangia e te herpes, ka whakataetae ia ki te deoxynucleoside mo te huaketo thymidine deoxynucleoside kinase, kinase pūtau ranei, ka whakapouritia te tarukino ki te acyclic guanosine triphosphate.Hei tïpako o te tukurua huaketo, ka whakataetae te acyclovir me te deoxyguanine triphosphate mo te DNA polymerase huaketo, e aukati ana i te whakahiatotanga o te DNA huaketo me te whakaatu i te paanga pareketo.Ko te mahi antiviral o tenei hua i roto i te vivo he pai ake i te acyclovir, a ko te tohu maimoatanga o te herpes simplex huaketo momo I me te momo II he 42.91% me te 30.13% teitei ake i te acyclovir.He nui hoki te mana whakaora ki te huaketo varicella zoster.