He pai te kounga 99% 2-Cyanobenzyl Bromide;Alpha-Bromo-O-Toluonitrile CAS: 22115-41-9

Ehara i te mea ka whakapau kaha matou ki te tuku kamupene tino pai ki nga kaihoko katoa, engari kua rite hoki ki te tango i nga whakaaro e tukuna ana e o maatau kaihoko mo te kounga pai 99% 2-Cyanobenzyl Bromide;Alpha-Bromo-O-Toluonitrile CAS: 22115-41-9, Ko te roopu o ta maatau umanga me te whakamahi i nga hangarau hou e tuku ana i nga taonga kounga tino pai e tino whakanuia ana, e maiohatia ana e o tatou wawata huri noa i te ao.
Ehara i te mea ka whakapau kaha matou ki te tuku kamupene tino pai ki nga kaihoko katoa, engari kua rite hoki ki te tango i nga whakaaro e tukuna ana e o maatau kaihoko.Haina 2-Cyanobenzyl Bromide Paura me Alpha-Bromo-O-Toluonitrile, E tino whakapono ana matou ko te hangarau me te ratonga ko to maatau turanga i tenei ra, ka hangaia e te kounga o tatou pakitara pono mo te heke mai.Ko taatau anake he pai ake, he pai ake te kounga, ka taea e taatau te whakatutuki i o taatau kaihoko me taatau ano hoki.Nau mai ki nga kaihoko puta noa i te kupu ki te whakapiri mai ki a maatau mo te whiwhi hononga pakihi me te pono.I konei tonu matou e mahi ana mo o hiahia i nga wa e hiahia ana koe.

Whakamahia:Takawaenga mo te Linagliptin.

Whakamahia:Takawaenga mo te Linagliptin
Paerewa Whakahaere:paerewa hinonga
Whakamātautau:98-102%

Waho:He ma ki te paura kowhai marama
Mōkī:25kg/pahū

Hei tātari i te linagliptin o naianei me tona takawaenga matua 8-bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1-[(4-methyl -2-quinazolinyl)methyl)-1H-purine- 2,6-dione (11) tikanga whakahiato, kimihia he ara waihanga e tika ana mo te hanga ahumahi.Tikanga: whakarāpopotohia ngā momo ara waihanga.Nga hua me nga whakatau: Ko te huarahi 2.2 he mahinga ngawari me te utu iti ake, he pai ake mo te hanga ahumahi.

Ko te 8-bromo-3,7-dihydro-3-methyl-1H-purine-2,6-dione he takawaenga matua mo te whakahiato o te linagliptin tarukino hypoglycemic.Ko te whakahiatotanga o te 1 e whakamahi ana i te methyl urea me te waikawa cyanoacetic hei rauemi timatanga, a ka uru ki nga tauhohenga e ono-taahiraa o te condensation, cyclization, nitrosation, reduction, cyclization, and bromine with the total yield of 46.3%.Ko nga hanganga o nga takawaenga katoa i whakapumautia e 1HNMR.

Ko te hangahanga o naianei e pa ana ki tetahi tikanga whakarite ngawari o te linagliptin tino parakore.Quinazoline, te takawaenga matua mo te whakarite-kohua o te linagliptin 8 bromo 7 (2 butyne 1 turanga) 3,7 dihydro 3 methyl 1 [(4 methyl 2 quinazolinyl) methyl] 1H Purine 2,6 dione, ka wehea te takawaenga e tātari, ka tauhohe ki te (R)3 aminopiperidine dihydrochloride kia whiwhi ai i tetahi otinga kei roto te linagliptin.I muri i te otinga o te linagliptin ka tukatuka ano, ko Deliraliptin te hua parakore.Ko te whakaritenga o te takawaenga matua o te tenenga o naianei ka tango i te tikanga kohua kotahi, he pai ki te whakahaere me te whakapai ake i te hua.I muri i te wehenga o te takawaenga matua, ka tauhohehia ki te (R)3 aminopiperidine dihydrochloride, na reira ko te whiwhi i te linagliptin parakore-nui ka tutuki hoki nga whakaritenga whakaputa me te whakapuakitanga o nga kamupene rongoa ki te whānuitanga nui.

Ehara i te mea ka whakapau kaha matou ki te tuku kamupene tino pai ki nga kaihoko katoa, engari kua rite hoki ki te tango i nga whakaaro e tukuna ana e o maatau kaihoko mo te kounga pai 99% 2-Cyanobenzyl Bromide;Alpha-Bromo-O-Toluonitrile CAS: 22115-41-9, Ko te roopu o ta maatau umanga me te whakamahi i nga hangarau hou e tuku ana i nga taonga kounga tino pai e tino whakanuia ana, e maiohatia ana e o tatou wawata huri noa i te ao.
He pai te koungaHaina 2-Cyanobenzyl Bromide Paura me Alpha-Bromo-O-Toluonitrile, E tino whakapono ana matou ko te hangarau me te ratonga ko to maatau turanga i tenei ra, ka hangaia e te kounga o tatou pakitara pono mo te heke mai.Ko taatau anake he pai ake, he pai ake te kounga, ka taea e taatau te whakatutuki i o taatau kaihoko me taatau ano hoki.Nau mai ki nga kaihoko puta noa i te kupu ki te whakapiri mai ki a maatau mo te whiwhi hononga pakihi me te pono.I konei tonu matou e mahi ana mo o hiahia i nga wa e hiahia ana koe.