Ka whakamahia te Ethylmethyl-carbamic chloride hei takawaenga o Rivastigmine tartrate.
Ko te Rivastigmine tartrate he rivastigmine nga raau mate a Alzheimer, ko te rivastigmine he physostigmine derivative na Novartis mo te wa tuatahi i pai te whakawhanake i te ingoa hokohoko Exelon (exelon), he ngota kei reira te hanganga carbamate, he momo waikawa amino o te aukati cholinesterase cerebral whiriwhiri, ka taea hoki te aukati. Ko te acetylcholinesterase me te butyrylcholinesterase, nga neurons cholinergic na roto i te whakaroa i te tukunga o te whakahekenga acetylcholine me te kaha e whakatairanga ana i te whakahaerenga nerve cholinergic, ka taea te whakapai ake i nga raruraru mahi hinengaro i takawaengahia e te cholinergic, na reira ka pai ake te mahi hinengaro o nga turoro mate o Alzheimer.He ngoikore te herenga pūmua plasma Rivastigmine, he ngawari ki roto i te arai toto-roro, he nui te tohu o te whiriwhiringa o te roro.Ehara i te mea ko te mahi maataki noa i runga i te uho roro me te hippocampus e tino pa ana, engari he pai ake te aukati i te momo-iti o te AChE i roto i te roro, na te mea ka heke te kaha o nga paanga taha cholinergic peripheral.Ko te Rivastigmine i roto i te vivo haurua-ora he poto me te roa o te mahi.Kaore i rite ki te tacrine, he kaha ake tenei hua i roto i te hippocampus me te uho o te G1 enzyme aukati.Ko te whare haumanu mo te maimoatanga o te ahua ngoikore o te ahua Alzheimer, te mate a Alzheimer ranei ka taea te whakapae he mate a Alzheimer.
JIN DUN Medical kuaKo te tohu ISO me te whakatutuki i nga paerewa whakaputa GMP, e mahi ana i nga tohunga whakahiato raau taero o roto me tawahi me te whai wheako nui hei arahi i te R&D a te kamupene.
TE WHAKAMAHI OGY
●High Pressure Catalytic Hydrogenation .Tauhohenga Hydrogenolysis High Pressure.Tauhohenga Cryogenic (<-78%C)
●Hangai Heterocyclic Aromatic
●Rearrangement Reaction
●Tauira Hira
●Heck, Suzuki,Negishi,Sonogashira .Tauhohenga Gignard
Nga taputapu
He maha nga taputapu whakamatautau me te whakamatautau, penei i te: NMR (Bruker 400M) 、HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Te Ngaruiti Ngaruiti, Te Whakarara Whakarara, Te Waahanga Matawai Rereke (DSC), Te Kaitiaki Irahiko...
R&D Team
Kei a Jindun Medical he roopu o nga kaimahi R&D ngaio, a he maha nga tohunga whakahiato tarukino o roto me nga iwi ke ki te arahi i te R&D, kia tika ake ai, kia pai ake ai to taatau whakahiato.
Kua awhinahia e matou etahi kamupene rongoa o roto, penei iHansoh, Hengrui me HEC Pharm.I konei ka whakaatuhia e matou tetahi waahanga o ratou.
Whakaritenga Take Tuatahi:
Nama nama: 110351-94-5
Take Whakaritea Tuarua:
Nama nama: 144848-24-8
Ritenga Take Tuatoru:
Nama cas: 200636-54-0
1.Whakaritea nga Takawaenga Hou, API ranei.He rite ano ki te tiritiri keehi i runga ake nei, kei nga kaihoko nga tono mo nga Kaiwawao motuhake, API ranei, a kaore e kitea nga hua e hiahiatia ana i te maakete, katahi ka awhina taatau ki te Whakaritea.
2.Tukatuka Arotautanga mo nga Hua Tawhito.Ka awhina to taatau roopu ki te Whakapaipai me te whakapai ake i nga mahi penei kua tawhito te huarahi tauhohenga, he nui te utu whakaputa, he iti te mahi.Ka taea e matou te whakarato i nga tuhinga katoa mo te whakawhiti hangarau me te whakapai ake i te tukanga, awhina i te kaihoko mo te mahi pai ake.
Mai i nga whaainga tarukino ki nga IND, ka tukuna e JIN DUN Medical ki a koenga otinga R&D motuhake kotahi-mutu.
Kei te tohe a JIN DUN Medical ki te hanga i tetahi roopu me nga moemoea, ki te hanga i nga hua rangatira, ki te tino mohio, ki te kaha, me te mahi katoa hei hoa pono me te hoa o nga kaihoko!